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LdrD-RdlD toxin-antitoxin system
RdlD RNA (regulator detected in LDR-D) is a family of small non-coding RNAs which repress the protein LdrD in a type I toxin-antitoxin system. It was discovered in ''Escherichia coli'' strain K-12 in a long direct repeat (LDR) named LDR-D. This locus encodes two products: a 35 amino acid peptide toxin (ldrD) and a 60 nucleotide RNA antitoxin. The 374nt toxin mRNA has a half-life of around 30 minutes while rdlD RNA has a half-life of only 2 minutes. This is in keeping with other type I toxin-antitoxin systems.〔
Northern blots showed that ''ldrD'' and ''rdlD'' are both transcribed and primer extension analysis showed the rdlD transcript is not translated.
Homologues exist in related Enterobacteriaceae such as ''Salmonella enterica'' and ''Shigella boydii''. The Ldr peptide genes that have been discovered are thought to have evolved from a common ancestor.〔
==LDR sequences==
Four long direct repeat (LDR) sequences were identified during genetic sequencing of a 718kb segment of the ''E. coli'' genome. One of these, LDR-D was studied further in order to determine the physiological function of these regions. The genes encoded by the other three LDRs, ''ldrA, ldrB and ldrC'' were confirmed to have the same activity as ''ldrD''.〔
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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